Tumor suppression by miR-26 overrides potential oncogenic activity in intestinal tumorigenesis

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2.

The hedgehog (Hh) signaling pathway regulates the development of many organs in mammals, and activation of this pathway is widely observed in human cancers. Although it is known that Hh signaling activates the expression of genes involved in cell growth, the precise role of the Hh pathway in cancer development is still unclear. Here, we show that constitutively activated mutants of Smoothened (...

متن کامل

Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis.

Despite its prevalence, the molecular basis of squamous cell carcinoma (SCC) remains poorly understood. Here, we identify the developmental transcription factor Grhl3 as a potent tumor suppressor of SCC in mice, and demonstrate that targeting of Grhl3 by a miR-21-dependent proto-oncogenic network underpins SCC in humans. Deletion of Grhl3 in adult epidermis evokes loss of expression of PTEN, a ...

متن کامل

‏‎suppression of coke formation in thermal cracking by coke inhibitors‎‏

‏‎the main purpose of this research was to:1.develop a coking model for thermal cracking of naphtha.2.study coke inhibition methods using different coke inhibitors.developing a coking model in naphtha cracking reactors requires a suitable model of the thermal cracking reactor based on a reliable kinetic model.to obtain reliable results all these models shall be solved simultaneously.for this pu...

15 صفحه اول

miR-22 in tumorigenesis

www.landesbioscience.com Cell Cycle 11 microRNAs (miRNAs), a newly characterized class of regulatory genes, have revolutionized classical biomolecular principles. These small non-coding RNAs, which are around 22 nucleotides long, negatively regulate gene expression through translational repression or targeting mRNAs for degradation. miRNAs function in multiple cellular processes, including prol...

متن کامل

Mir 145/143: tumor suppressor, oncogenic microenvironmental factor or …both?

literature regarding the role of mir-143/145 in tumor initiation/progression. Herein, we aim to contribute our experience and observations to this ongoing debate. We will start from the experimental data presented in the outstanding work of the Tyler Jacks lab, by Dimitrova, Gocheva and colleagues [6]. They show, in a kRAS/p53 murine model of lung adenocarcinoma, that the contribution of the mi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Genes & Development

سال: 2014

ISSN: 0890-9369,1549-5477

DOI: 10.1101/gad.250951.114